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Description

Studies including healthy individuals were not eligible unless they were incorporated as a comparator or control group alongside participants with PD

One approach involves antioxidant therapies aimed at neutralizing the ROS generated by pyocyanin or boosting endogenous antioxidant defenses such as glutathione (206)

7 = 2,33

A promising antioxidant appears to be ergothioneine, however, double-blind placebo-controlled trials have to be conducted

Lancet 395, 497506

The metabolic adaptive mechanism has introduced new challenges to treatment, and there is an urgent need to develop a joint treatment strategy that targets multiple key metabolic nodes simultaneously