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First, given the very low expression of target (pHLA) in latently infected cells due to blocks in proviral transcription and translation, we anticipate that a multiple-dose schedule incorporating higher doses will be needed to provide sufficient target occupancy to drive substantial killing of infected cells and thereby achieve the multi-log reductions that are deemed necessary for long-term viral control 61

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Initial treatment for sepsis and renal failure, including intravenous bicarbonate and dialysis, failed to correct the acidosis

The groups were labeled as follows: Group 1 rats served as the control and were not injected with a peptide