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Giblin FJ

J Neurosci 1990

Ruiz AG, Casafont F, Crespo J, Cayon A, Mayorga M, et al

Therefore, directing CDK5 to the nucleus or exporting tumor-suppressive nuclear substrates to the cytoplasm may be promising approaches to combat CDK5-induced oncogenicity, analogous to neurotoxicity triggered by nuclear CDK5

Contrary to alternative method based on a competitive hypothesis, GSVA is based on self-contained null hypothesis which analyzes each gene set in isolation, assessing differential expression of the gene set without comparing to a background [62, 63]