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Numerous studies have shown that lactoferrin (Lf) receptors (LfRs), expressed on the capillary endothelial cells of the brain, transport Lf across the BBB through transcytosis [23, 24]

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Re-expressing cell lines of HMOX2 WT, HW/GW mutant, or K68R mutant were analyzed by immunofluorescence with anti-HA, anti-Calnexin, and anti-Tom20 antibodies to visualize the localization of HMOX2, ER, and mitochondria, respectively