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Moreover, NK4 is structurally similar to angiostatins, which is why it possesses anti-angiogenic activity

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M1 macrophages have metabolic reprogramming associated to Warburg effect, high NO output, high antigen presentation, and pro-inflammatory cytokine production (IL-1, IL-6, IL-12, IL-23, and CXCL9), allowing them to establish a powerful immune response against intracellular pathogens