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The high similarity to the previously reported SUV-binding modes suggest that S, in a similar manner as the so-called horse-shoe model 22 , has an intrinsic propensity to form the necessary kink in the membrane-binding interface

Arora S , Yilmaz M, Jen W, Short NJ, Loghavi S, Kadia TM, DiNardo CD, Borthakur G, Deshmukh I, Issa GC, Jabbour JE, Pemmaraju N, Andreeff M , Takahashi K, Bhalla KN, Abbas HA, Garcia-Manero G, Ravandi F, Kantarjian HM, Daver N

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