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Pernicious anemia often leaves individuals feeling exhausted and weak, as a lack of B12 prevents the body from producing enough red blood cells, which are responsible for carrying oxygen to tissues and organs

Chronic Disease Chronic diseases may promote the development of RLS, or worsen its symptoms

Trial of anti-BDCA2 antibody litifilimab for cutaneous lupus erythematosus

Electrolyte Imbalance Low levels of magnesium, potassium, calcium, or sodium disrupt the electrochemical signals that tell muscles to contract and then relax

2004 Mar;89(3):1217-21

The Myth of B12 as a Performance Enhancer The Mayo Clinic weighs in definitively on this topic: Some researchers have studied vitamin B-12 to find out if it can raise energy and endurance during exercise