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MCT4 blockade increases the efficacy of immune checkpoint blockade

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C.W., J.S., X.Q., H.W., W.H., X.L., Y.L., X.Z., K.D., Y.L., H.L.,Y.L., S.G., X.Y., T.B., Y.X.: conducted the experiments

Large-fibre injury usually occurs later in the disease course, but this is not always the case

A study by Booth et al

the multifunctional growth factor hepatocyte growth factor (HGF) and its receptor Met are important mediators for mitogenesis, motogenesis, and morphogenesis in a wide range of cell types (Birchmeier et al., 2003) including epithelial (Kakazu et al., 2004), endothelial (Kanda et al., 2006), and hematopoietic cells (Ratajczak et al., 1997), neurons (Thompson et al., 2004), melanocytes (Halaban et al., 1992), and hepatocytes (Borowiak et al., 2004)