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Statements Author contributions SS: Writing original draft, Methodology, Data curation

Kat: One thing I wanted to talk about, we have five kids and our youngest had some kind of pretty serious health stuff that went on when he was about one year old

Fork head box O transcription factor 4-D-Retro Inverso (FOXO4-DRI), a synthetic isoform of the transcription factor FOXO4, triggers apoptosis of senescent cells by disrupting the interaction between FOXO4 and p53 and releasing p53 into the cytosol

Mosby Elsevier

It remains in Phase 3 clinical trials through the TRIUMPH program, which includes multiple studies examining different patient populations and endpoints