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In healthy individuals, adipocytes secrete adiponectin, which induces M2-like polarization of ATM and suppresses ROS and its related pathway genes ( 2.3 Sources of ROS production Though the primary source of ROS in vivo is through aerobic respiration, cellular events, including peroxisomal -oxidation of fatty acids, arginine metabolism, tissue-specific cellular enzymes and phagocytosis stimulation by pathogens also contributed to ROS production ( The NADPH oxidase (NOX) family of proteins remains the primary cytosolic source of ROS, consist of seven different isoforms and comprises membrane and cytosolic components that are actively involved in the host response to various stimuli including bacterial and viral infections, cellular signaling and regulation of gene expression

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T2DM causes microvascular and neurological complications in numerous cases

10.1161/circresaha.117.311586 147 JinL.GengL.YingL.ShuL.YeK.YangR.et al (2022a)

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Early Termination of ISRCTN45828668, a Phase 1/2 Prospective, Randomized Study of Sulfasalazine for the Treatment of Progressing Malignant Gliomas in Adults