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Consequently, SSB2 exhibits anti-ferroptosis and anti-neuroinflammatory effects, attenuating the activation of the LPS-induced primary microglial TLR4/NF-B signaling pathway in a GPX4-dependent manner (Wang et al., 2023c)

Front Pharmacol 5:151 Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

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The research was supported in part by the National Institute of Dental and Craniofacial Research (R01DE025037 and R01DE027374).