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However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis

One retrospective study in 123 septic patients and 246 matched controls found that intravenous thiamin administration within 24 hours of hospital admission was linked to improvements in both lactate clearance and 28-day mortality (102)

[Abstract]2020 Jan 30;12(2):1808-1827

T., Sulka, K

Extracts from the clinical evidence

(25, 26) With this explanation in hand, lets now talk about some of the research that has been done regarding the optimization of selenium in people with various thyroid issues, including Hashimotos, seleniums synergistic effects with myo-inositol, hypothyroidism relating to pregnancy, and autoimmune hyperthyroidism (Graves disease)