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Furthermore, inhibition of PI3K, Akt, or Smad2 could suppress CSE-induced alterations in epithelial and mesenchymal marker expression [107]

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That study included data from the National Survey on Drug Use and Health suggesting that, in 2006, 73.89% of people surveyed said cigarette smoking posed a great health risk, but in 2015, that percentage dropped to 72.89%