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Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e.g., barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased

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Correlation analysis Single and multiple linear and logistic correlation analyses were performed using data from all 320 samples analysed to assess the impact of nicotine and cotinine in the FF on MAR outcomes