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Funding This study was supported by grants from the National Heart, Lung, and Blood Institute of the National Institutes of Health (R01 HL142511) to YT and MLG, the US Food and Drug Administration (FDA), and the National Cancer Institute Grant U54CA228110 to MLG, and P30CA016056 involving the use of Roswell Park Core facilities

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22nd Century Reports Momentum for VLN Products 22nd Century Group touted early sales momentum for its VLN low-nicotine cigarettes, distributing approximately 8,800 cartons to about 1,700 new retail outlets nationwide in the fourth quarter of 2025, with initial sell-through data indicating growing adoption across its 22nd Century VLN, Pinnacle VLN, and Smoker Friendly VLN brands

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