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Evidence from a population pharmacokinetics analysis for a major effect of CYP1A2 activity on inter- and intraindividual variations of clozapine clearance

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As cigarettes are much more lethal than ENDS, the high rate of substitution estimated here suggests that, on net, any population health benefits of ENDS flavor policies are likely small or even negative. Although flavored ENDS products remain widely available in states that do not prohibit their sales, the studys authors noted, the FDA seems to be paving a path towards a de facto national ENDS flavor prohibition. That policy, they said, entails an inequitable tradeoff because it prioritizes youth over the 11.2% of US adults [who] smoke. Since the FDA has not made a serious effort to enforce its de facto ban against the thousands of suppliers who are theoretically violating it, adults can still purchase ENDS in a wide variety of flavors from vape shops, tobacconists and online vendors

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