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During their visit, John Rolfe wrote "A True Relation of the State of Virginia Lefte by Sir Thomas Dale Knight in May Last 1616" The manuscript was published in 1617 and further touted the viability of the colony in Virginia

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On the tobacco plant Nicotiana attenuata , young leaves close to a plant's stem are more protected from predators and larvae that grow there gain more mass than larvae grown elsewhere on the plant

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Annual smoking-attributable mortality, years of potential life lost, and economic costsUnited States, 19951999

United States [edit] A historian of the American South in the late 1860s reported on typical usage in the region where it was grown: [39] The chewing of tobacco was well-nigh universal