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10 Facts about the Skull of a Skeleton with Burning Cigarette by Van Gogh The skull of a skeleton with burning cigarette is one of Van Goghs earliest paintings, though undated the small oil-on -canvas painting which features a skeleton and a cigarette was most likely painted in the winter of 1885-86 as a satirical comment of conservative academic practices

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Treatment with CS markedly induced the phosphorylation of histone H3 at serine 10 and 28 residues [54], as well as histone H2AX [55], in a dose- and time-dependent manner

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