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Based on coat protein antigenicity, TNV is divided into at least two major serotypes: Serotype A (TNV-A) and Serotype D (TNV-D)

When triggered by factors such as stress, sunlight, hormonal shifts, or immune suppression, the virus reactivates and travels back to the skin, causing recurrent lesions or asymptomatic shedding [4]

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9 , 10 ENDS use was also implicated in adverse effects on the head, neck, oral cells regarding aberrant morphology, cytotoxicity, reduced viability, delayed fibroblast migration and genotoxicity