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Despite regulatory constraints in many regions, flavor innovation remains a critical driver of market competitiveness

Footnote xxix Questions: Would these results likely be different in Canada

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Food and Drug Administration (FDA) has regulatory authority over synthetic nicotine as it does over tobacco-derived nicotine

Its important to note that this pack year formula only applies to manufactured cigarettes

These differences arise from a combination of the quantity of each toxicant present in the cigarette smoke entering the filter (in which isoprene, acetaldehyde and acetone are the major constituents by mass concentration) and the efficiency of HAC towards individual smoke constituents