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Hence, the FDA recommends close monitoring of neuropsychiatric symptoms in patients receiving bupropion and to stop bupropion therapy if any contraindications were to be found ( 92 )

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This combination is favored due to its manageable side effect profile and has shown significant activity in advanced anal cancer, particularly in the InterAAct trial , where carboplatin plus paclitaxel was associated with better tolerability compared to cisplatin-based regimens ( Rao et al., 2020 )