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While our study does not conclusively address whether any or all of the brain changes are a direct consequence of marijuana use, these effects do suggest that these changes are related to age of onset and duration of use. The study, published in the journal Proceedings of the National Academy of Sciences, suggests that grey matter may be more vulnerable to the effects of THC, the main active ingredient in cannabis, than white matter

doi: 10.3390/ijerph7010146

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