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Cigarettes: real facts The Real Cost Diseases and Death CDC Tobacco Statistics & Facts ASH > Action on Smoking & Health How Many People Die From Smoking? Tobacco Chart (2026) Smoking is a major cause of cardiovascular disease, which is the single leading cause of death in the U.S. Smoking causes one of every five deaths from cardiovascular disease. Learn more about Smoking may be trending on social media, but increasing your risk of cancer is certainly not cool. Smoking tobacco increases your risk for lung and at least 15 other types of cancer.
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