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For the non-specialist, this statistical pattern a large, significant indirect effect through the mediator coupled with a non-significant direct effect is highly suggestive of a model in which systemic inflammation serves as the predominant pathway linking smoking to higher mortality in this patient population

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Congress tends to broadly write public health laws, often using open-ended phrases such as in the public interest or to promote health. Since the Chevron case, federal agencies have used their expertise to fine-tune statutes, such as EPA creating rules to limit carbon emissions, CMS ensuring basic medical services are covered in health insurance plans and FDA regulating the safety of drugs and vaccines

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PMC 5771050

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