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Nicotine is unique in comparison to most drugs, as its profile changes from stimulant to sedative/pain killer in increasing dosages and use, a phenomenon described by Paul Nesbitt in his doctoral dissertation [27] and subsequently referred to as "Nesbitt's Paradox"

Addict Behav 39:16821689 Shenhav A, Musslick S, Lieder F, Kool W, Griffiths TL, Cohen JD, Botvinick MM (2017) Toward a rational and mechanistic account of mental effort

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Zyn on the other hand contains mostly synthetic materials derived from tobacco and other artificial flavorings

For example: The most recent Annual National Youth Tobacco Survey revealed that more than 14% of high school students vapedthats about 2.14 million teenagers