Azide-Dap(m-PEG4)-Val-Cit-OH biotin ZXH-1-161 is a potent cereblon

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1

(2) Yamazoe

and CDr17 utilizes GLUT1 to enter M1 macrophages

Product Name DOTA-tris(t-Bu)ester-PEG5-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C40H76N8O12 Molecular Weight 861

438 SMILES CC(C)(C)C1=CC=CC(OC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Azide-Dap(m-PEG4)-Val-Cit-OH biotin ZXH-1-161 is a potent cereblonSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine