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4 The role of the endothelial cell glycocalyx in sepsis 4.1 Early damage and the vicious circle of endothelial glycocalyx pathology in sepsis Sepsis is a systemic disease, but the vascular endothelium is the first site that is exposed to bacterial endotoxin

A 2010 study using the Broad Institute's Connectivity Map database found that GHK-Cu at physiologic doses modulated approximately 31% of the 16,000+ human genes evaluated, shifting gene expression toward a more youthful pattern

Wang J, Shanmugam A, Markand S, Zorrilla E, Ganapathy V, Smith SB

Gupta, De Felice, Loftus, & Khanna, 2015)

Its presence seems to disrupt AR and FOXA1 signaling [66]