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Oral administration provides lower systemic exposure but is preferred for gastrointestinal targets

It also modifies histones, thereby disrupting chromatin structure and generating genotoxic histoneDNA crosslinks [116]

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A region in the brain called the hypothalamus regulates body temperature

This activation promotes localized inflammatory and fibrotic responses in the kidney by enhancing inflammatory factors MCP-1 and fibrotic markers such as collagen I and III [74]