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48 Parkinsons disease Aside from the aggregation of misfolded -synuclein in the intracellular Lewy bodies, a major neuropathological hallmark of PD is the loss of dopaminergic neurons within the SN

a diagnostic procedure used to assess microvascular function and endothelial health to evaluate blood flow changes in response to temporary occlusion of an artery), combined with microcirculatory parameters (e.g., blood flow response), achieved 84.6% accuracy in diagnosing DPN

While these interactions do not establish direct causality, they provide integrative evidence linking metabolomic alterations to gene networks previously implicated in neurodevelopmental and metabolic regulation

MVD-affected dogs in heart failure have been shown to have significantly higher circulating levels of TMAO in their blood serum compared to healthy dogs and to dogs with pre-CHF MVD

n= 359 control), the pooled estimate favored ALC (SMD 1.20, 95% CI 2.12 to 0.29