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Clinical scenarios and decision-making framework Different patient situations call for different approaches

The NHS Inform Scotland guidance and the Vegan Societys recommendation align: a 10-microgram daily B12 supplement, or a 2,000-microgram weekly supplement, is enough for the vast majority of plant-based eaters

Vitamin B12 is well-established for red blood cell formation, neurological function, DNA synthesis, and cellular metabolism

Non-alcoholic fatty liver disease (NAFLD) affects a majority of individuals with obesity

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Evidence level: Preclinical evidence only Sources: Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction