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10.1111/ejn.13357 [DOI] [PMC free article] [PubMed] [Google Scholar] Lolicato F, Juhola H, Zak A, Postila PA, Saukko A, Rissanen S, Enkavi G, Vattulainen I, Kepczynski M, Rg T, 2020

In addition to improving mitochondrial respiration and electron transport chain activity, -KG replenishes TCA cycle intermediates, which raises the production of ROS (Martnez-Reyes and Chandel, 2020

However, opportunities to enhance ADSC therapy include the development of gene-modified ADSCs to overexpress angiogenic or neurogenic factors, the use of exosome-based therapies, and combining ADSCs with other regenerative techniques like low-intensity shockwave therapy

ALA may help correct several mechanisms involved in DPN, including sorbitol accumulation, microvascular damage, oxidative stress, and lipid peroxidation [16]

A proposed role in ascorbic acid metabolism

Collection of the eluted target in a neutral pH buffer and regeneration the column as soon as possible after the elution step can overcome this problem [8]