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Specifically, treatment upregulates the molecular chaperone GRP78 to enhance protein-folding capacity and promote adaptation, while concurrently inhibiting the pro-apoptotic PERK/eIF2/CHOP axis and downstream activation of caspase-12 and caspase-3

In our society, these symptoms are considered normal signs of aging. In truth, they are signs of abnormal or accelerated aging processes

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Interfaces 12 , 3583535844 (2020)

To contend with these insults, our bodies are equipped with a cytoprotective mechanism for survival