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If the release of sVEGFR1 by GrK can also be induced in vivo , this could have a double or triple anti-tumor effect by inhibiting angiogenesis, and by reducing survival signaling pathways in tumor cells

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As the catalytic His 18 is conserved in both enzymes, the independence of pH for product specificity in both enzymes is consistent with each enzyme preferring a certain binding mode for SA

Cells were infected with lentivirus at 50% confluence in the presence of 10 g/mL polybrene for 24 h