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Nearly 2.5 billion individuals will suffer from hearing loss by 2050, according to the World Health Organization (WHO), comprising a minimum of 700 million individuals expected to need hearing rehabilitation (Chadha et al

Thiamin is crucial for energy metabolism and supports normal nervous system functions

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

Therefore, targeting the BCL-2 family proteins in combination with targeting metabolic vulnerabilities is a viable strategy for eliciting deeper responses and overcoming therapy resistance in MM (124)