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Mandell notes that the approval announcement says leucovorin can help children with CFD and that, because these children have some autism-like symptoms, therefore we should consider it as a treatment for autism, Mandell says

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Their ability to interpret these reports is limited by missing information and confounding factors like concurrent medications

Consistent subcutaneous injection technique is part of accurate dosing

Animal safety data has not identified a toxic dose, but that does not replace physician guidance