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Same lighting conditions, camera angle, hair styling (or lack thereof), and time of day reduce variability that masks or exaggerates apparent changes

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However, l-dopa possesses many pharmacokinetic and pharmacodynamic drawbacks leading to pulsatility (short half-life), reduced availability (limited and variable reabsorption, and the requirement for declining aromatic l-amino acid decarboxylase), and off-target metabolism and sites (endothelium, glial cells, serotonin neurons and so on)

Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids

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