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Suntres ZE (2018) Exploring the potential benefit of natural product extracts in paraquat toxicity

(Figure 3A,B) Consider in vivo GSH concentration of 110 mM, second-order reaction rate k GSH around 0.048 0.48 M 1 min 1 translates to a half-life of 24 h

Double induction (DI) chemotherapy for patients (pts) with newly diagnosed acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS)

In the oxidative half of the mechanism, Cys63 nucleophilically attacks the nearest sulfide unit in the glutathione disulfide (GSSG) molecule, which creates a mixed disulfide bond (GS-Cys58) and a GS- anion