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Structurally, it is the only GPX isoform with a monomeric conformation and a unique catalytic tetrad including Sec, Gln81, Trp136, and Asn137 that enables it to reduce complex hydroperoxides in situ even within membranes ( Transcriptionally, GPX4 expression is promoted by Nrf2 and ATF4 in response to oxidative or endoplasmic reticulum stress

Maturation of mast cell progenitors to mucosal mast cells during allergic pulmonary inflammation in mice

Additionally, in cell culture experiments, NAC protected against H3N2 influenza virus-induced oxidative stress, cell death, the expression of inflammatory genes, and NF-B activity [62,63]

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2015 gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative