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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible

[3] The regulation of levels of ROS, levels of oxidized and reduced glutathione and other thiols, and antioxidant enzymes (such as GSTs and glutathione reductase) are important in determination of the most stable conditions for redox control, or for activation of apoptosis

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Therefore, both NRF2 and HES1 in skin fibroblasts are essential in skin homeostasis maintenance and aging protection

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Sclerotherapy may be used alone or to complement surgical procedures in the treatment of chronic venous insufficiency (Scherger 2012)