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Like NO, prostacyclin is another endothelium-derived vasoactive substance that serves as a potent vasodilator and inhibitor of platelet aggregation [63]

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All secondary antibodies were purchased from Cell Signaling Technology (4408, 4409, 4412, 4413, Carlsbad, USA)

Interestingly, the negative regulatory effect of APR-017 and LCS3 on GSH synthesis in VRK2-KO cells was reversed by VRK2 rescuing (Fig