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Additionally, SF (5.64 mol/kg/day for 15 days) demonstrated therapeutic effects in a rat model induced with nicotinamide and streptozotocin by restoring insulin levels, normalizing motor coordination, improving sensory responses, and ameliorating histopathological changes (123)

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Although TAA expression was heterogeneous across tumors, the recurrent involvement of STAT3- and IDO1-driven pathways underscores their roles in tumor proliferation, immune evasion, and metastatic progression (142, 146, 147)