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S1C) indicating that the T94 2.61 I substitution is the responsible for the blue-shift, from 500 nm to 478 nm, observed in the other double mutants and in the triple mutant

Generation of stable MCF7 cell lines expressing wild-type GSTP1 tagged with V5 at the NH 2 and COOH termini and V5_GSTP1 mutants Generation of the MCF7-GSTP1 (untagged) and MCF7-vector stable cell lines was described previously [24]

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When administered together, typically as a combined injection, the two mechanisms produce a synergistic GH response: the GHRH receptor activation from CJC-1295 primes the pituitary for a larger and more prolonged release, while Ipamorelin provides the GHS-R1a signal that triggers the pulse

Amsterdam: EMA