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Since Nrf2 must be dissociated from kelch-like ECH-associated protein-1 (Keap1) in order to migrate to the nucleus, Keap1 acts as an inhibitor of Nrf2, which retains the Nrf2 protein in the cytoplasm and prevents the transcription of downstream target genes [20,21]

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Combined GSH and AA homeostasis impairment and hyperdopaminergic state in Trkb Penk -KO mice affects energy metabolism, impacting neuronal viability before the onset of motor symptoms