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Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimers disease (5FAD) mice, reduced A and IL-6 levels, inhibited A plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice ( 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, -secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and -secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and A plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice ( G93A transgenic mice, significantly reduced the expression of FTL, FTH, Ferritin, TFR1, and APP, upregulated FPN1 expression, inhibited A and iron accumulation in skeletal muscle, and improved neural function in the mice

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J Clin Invest (1998) 101(4):7618

doi: 10.1007/s11010-014-2044-0 60 DoHTTselykhTVMkelJHoTHOlkkonenVMBornhauserBCet al